Description

Trifluoro-p-Tolunitrile CAS NO 455-18-5 is a high-purity fluorinated aromatic nitrile building block essential for advanced chemical synthesis. Its unique structure, featuring both a nitrile group and a trifluoromethyl substituent on the benzene ring, makes it a versatile intermediate for introducing fluorine-containing motifs into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to enhance the metabolic stability, lipophilicity, and binding affinity of their products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystals used in high-performance displays (LCDs).
• Organic Electronics: Employed in the synthesis of electron-deficient units for organic semiconductors, OLEDs, and perovskite solar cells.
• Fluorinated Polymer Modifiers: Acts as a monomer or modifier to introduce fluorine into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Advanced Material Research: A valuable reagent in academic and industrial R&D for creating novel fluorinated compounds with tailored properties.

Basic Information

Product Name	Trifluoro-p-Tolunitrile
CAS No.	455-18-5
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	4-(Trifluoromethyl)benzonitrile; α,α,α-Trifluoro-p-tolunitrile; p-Cyanobenzotrifluoride; 4-Cyanobenzotrifluoride; 4-Trifluoromethylbenzonitrile; Benzonitrile, 4-(trifluoromethyl)-; NSC 404058; p-Trifluoromethylbenzonitrile
EINECS	207-247-7

Quality Control

Our Trifluoro-p-Tolunitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliable supply and consistent quality for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥98.0% (Standard Grade)
Purity (GC/HPLC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.