Description

2-Bromomethyl-1-Fluoro-4-Nitrobenzene is a versatile and high-purity halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromomethyl, fluoro, and nitro functional groups, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on the synthesis of novel active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in electronic and display material development.
• Cross-Coupling Reactions: The bromomethyl group is reactive in palladium-catalyzed cross-couplings (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Functional Polymer Monomer: Employed in the development of specialty polymers with tailored thermal, optical, or surface properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-Bromomethyl-1-Fluoro-4-Nitrobenzene
CAS No.	454-15-9
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	1-Fluoro-2-(bromomethyl)-4-nitrobenzene; 2-Bromo-1-fluoro-4-nitrobenzyl bromide; 4-Nitro-2-(bromomethyl)fluorobenzene; α-Bromo-2-fluoro-5-nitrobenzyl bromide; 2-Fluoro-α-bromo-5-nitrobenzyl bromide; (2-Fluoro-5-nitrophenyl)methyl bromide; 2-(Bromomethyl)-1-fluoro-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromomethyl-1-Fluoro-4-Nitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.