Description

4-Methylsulfonyl-2-Nitrofluorobenzene is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a reactive methylsulfonyl substituent ortho to a fluorine atom, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based drugs and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its reactive sites for structural diversification.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments due to its nitro-aromatic core.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures.
• Nucleophilic Aromatic Substitution: The activated fluorine atom makes it an excellent electrophile for reactions with various nucleophiles in medicinal chemistry.

Basic Information

Product Name	4-Methylsulfonyl-2-Nitrofluorobenzene
CAS No.	453-72-5
Molecular Formula	C7H6FNO4S
Molecular Weight	219.19 g/mol
Synonyms	1-Fluoro-2-nitro-4-(methylsulfonyl)benzene; 2-Nitro-4-(methylsulfonyl)fluorobenzene; 4-Fluoro-3-nitrobenzenesulfonylmethane; 4-(Methylsulfonyl)-2-nitro-1-fluorobenzene; 2-Nitro-4-methylsulfonylfluorobenzene; Benzenesulfonylmethyl, 4-fluoro-3-nitro-; 4-Methylsulphonyl-2-nitrofluorobenzene
EINECS	Contact for details

Quality Control

Our 4-Methylsulfonyl-2-Nitrofluorobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We are committed to meeting the stringent requirements of our global B2B clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.