Description

3-Fluoro-4-Nitroanisole is a versatile aromatic nitro compound and a key fluorinated building block in advanced organic synthesis. Its value lies in its unique molecular structure, which combines electron-withdrawing nitro and fluoro groups with an electron-donating methoxy group, making it an essential intermediate for constructing complex molecules. This compound is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic core.
• Agrochemical Synthesis: Used in the development of advanced herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and stability.
• Dye and Pigment Manufacturing: Serves as a building block for synthesizing specialized dyes and pigments, leveraging its nitro group for chromophore development.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where specific electronic properties are required.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig amination for creating biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it an excellent candidate for displacement reactions to introduce various functional groups.

Basic Information

Product Name	3-Fluoro-4-Nitroanisole
CAS No.	446-38-8
Molecular Formula	C7H6FNO3
Molecular Weight	171.13 g/mol
Synonyms	1-Fluoro-2-Methoxy-5-Nitrobenzene; 3-Fluoro-4-Nitrophenyl Methyl Ether; 4-Nitro-3-Fluoroanisole; 2-Methoxy-5-Nitrofluorobenzene; 5-Nitro-2-Fluoroanisole; Anisole, 3-fluoro-4-nitro-; Benzene, 1-fluoro-2-methoxy-5-nitro-
EINECS	207-177-6

Quality Control

Our 3-Fluoro-4-Nitroanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, confirming compliance with agreed specifications and supporting your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.