Description

2,4-Difluoronitrobenzene is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and fluorine substituents, makes it a critical intermediate for constructing complex molecules with high precision. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated benzene rings.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides where the difluoronitrobenzene moiety imparts desired biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Dye & Pigment Manufacturing: Intermediate for producing complex, high-performance colorants and fluorinated dyes.
• Cross-Coupling Reactions: Valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated fluorine atoms allow for selective displacement with various nucleophiles, enabling diverse functionalization.
• Research & Development: Used in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Item	Details
Product Name	2,4-Difluoronitrobenzene
CAS No.	446-35-5
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	1,3-Difluoro-4-nitrobenzene; 2,4-Difluoro-1-nitrobenzene; 4-Nitro-1,3-difluorobenzene; NSC 404044; Benzene, 1,3-difluoro-4-nitro-; 2,4-DFNB
EINECS	207-173-6

Quality Control

Our 2,4-Difluoronitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Pale yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	28 - 32 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.