Description

1-Bromo-4-Fluoro-2-Nitrobenzene is a versatile halogenated nitroaromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it a highly valuable intermediate for constructing complex molecules with tailored properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific functional groups into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine and nitro groups enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex organic dyes and pigments, leveraging its nitro and halogen functionalities.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling the formation of new carbon-carbon and carbon-heteroatom bonds.
• Chemical Research & Development: A standard reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	1-Bromo-4-Fluoro-2-Nitrobenzene
CAS No.	446-09-3
Molecular Formula	C6H3BrFNO2
Molecular Weight	220.00 g/mol
Synonyms	4-Fluoro-2-nitro-1-bromobenzene; 2-Nitro-4-fluorobromobenzene; 1-Bromo-4-fluoro-2-nitrobenzene; 4-Fluoro-2-nitrobenzyl bromide (common misnomer); 2-Bromo-5-fluoronitrobenzene; 446-09-3; NSC 406906; p-Fluoro-o-nitro bromobenzene
EINECS	207-172-6

Quality Control

Our 1-Bromo-4-Fluoro-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global B2B clientele. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.