Description

2-Fluoro-1-Methoxy-3-Nitrobenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring electron-withdrawing nitro and fluorine substituents adjacent to a methoxy group, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated aromatic core.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes.
• Dye & Pigment Manufacturing: Employed in the production of specialized dyes and pigments, where the nitro group facilitates chromophore formation.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects.

Basic Information

Product Name	2-Fluoro-1-Methoxy-3-Nitrobenzene
CAS No.	445-68-1
Molecular Formula	C7H6FNO3
Molecular Weight	171.13 g/mol
Synonyms	1-Fluoro-2-Methoxy-5-Nitrobenzene; 2-Fluoro-3-Nitroanisole; 3-Nitro-2-fluoroanisole; 2-Methoxy-6-fluoronitrobenzene; 5-Nitro-2-fluoroanisole; 2-Fluoro-3-nitro-1-methoxybenzene; 2-Fluoro-3-nitrophenyl methyl ether
EINECS	207-174-8

Quality Control

Our 2-Fluoro-1-Methoxy-3-Nitrobenzene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be stored away from light. It is also easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.