Description

2 α-Methyl-9 α-Fluorocortisol is a synthetic fluorinated corticosteroid derivative, known for its potent glucocorticoid and mineralocorticoid activity. This compound is a critical intermediate in pharmaceutical research and development, particularly for the synthesis of advanced steroid-based therapeutics. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the development of anti-inflammatory agents, dermatological preparations, and endocrine research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical and systemic corticosteroids.
• Biochemical Research: Used as a reference standard and active agent in studies of glucocorticoid receptor binding and activity.
• Anti-inflammatory Agent Development: Serves as a precursor for novel compounds targeting inflammation and immune response pathways.
• Dermatological Formulations: Employed in the research and development of creams and ointments for treating skin conditions like eczema and psoriasis.
• Endocrinology Studies: Utilized to investigate mineralocorticoid effects and adrenal cortex function in laboratory settings.
• Veterinary Medicine: Applied in the development of anti-inflammatory treatments for animals.

Basic Information

Product Name	2 α-Methyl-9 α-Fluorocortisol
CAS No.	432-34-8
Molecular Formula	C23H31FO5
Molecular Weight	406.49 g/mol
Synonyms	9α-Fluoro-2α-methylcortisol; 2α-Methyl-9α-fluorocortisol; 9α-Fluoro-2α-methylhydrocortisone; 2α-Methyl-9α-fluorohydrocortisone; Fludrocortisone 2α-methyl derivative; NSC 47439; 2-Methyl-9-fluorocortisol
EINECS	Contact for details

Quality Control

Our 2 α-Methyl-9 α-Fluorocortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.