Description

1,2-Dihydro Dexamethasone is a key pharmaceutical intermediate and a derivative of the potent glucocorticoid dexamethasone. This compound matters for its critical role in the synthesis and research of advanced steroid-based therapeutics, offering a pathway to molecules with modified biological activity. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in developing new anti-inflammatory, immunosuppressive, and oncological treatments.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel corticosteroid analogs and prodrugs.
• Research & Development: Used in medicinal chemistry programs to study structure-activity relationships (SAR) of glucocorticoid receptor modulators.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Employed in metabolic studies to investigate the pathways and derivatives of dexamethasone.
• Fine Chemical Synthesis: Utilized for the custom synthesis of specialized steroid compounds for clinical and preclinical evaluation.

Basic Information

Product Name	1,2-Dihydro Dexamethasone
CAS No.	426-17-5
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 1,2-Didehydrodexamethasone; Dexamethasone Impurity C; (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydrodexamethasone; NSC 113927
EINECS	Contact for details

Quality Control

Our 1,2-Dihydro Dexamethasone is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided to ensure traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.