Description

3-Fluoro-4-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a cyano group and a hydroxyl group ortho to a fluorine atom, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies, leveraging its polarizable aromatic core and fluorine substituent.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the creation of high-performance polymers, such as polyamides, polyesters, and epoxy resins, imparting thermal and chemical resistance.
• Organic Electronic Materials: Employed in the research of organic semiconductors, OLEDs, and photovoltaic materials due to its electron-withdrawing character and potential for functionalization.
• Chemical Research & Development: A valuable building block in medicinal chemistry, process chemistry, and material science for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	3-Fluoro-4-Hydroxybenzonitrile
CAS No.	405-04-9
Molecular Formula	C7H4FNO
Molecular Weight	137.11 g/mol
Synonyms	4-Cyano-2-fluorophenol; 2-Fluoro-4-hydroxybenzonitrile; 4-Hydroxy-3-fluorobenzonitrile; 3-Fluoro-4-hydroxybenzenecarbonitrile; 2-Fluor-4-hydroxybenzonitril (German); 3-Fluoro-4-cyanophenol; Benzonitrile, 3-fluoro-4-hydroxy-; 405-04-9
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Hydroxybenzonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Custom purity grades, including research and pharmaceutical intermediates, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	145 - 150 °C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.