Description

1-(Difluoromethyl)-3-Nitro-Benzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a difluoromethyl and a nitro group on the benzene ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to introduce fluorine-containing motifs into target molecules, thereby modulating their biological activity, metabolic stability, and physicochemical characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the difluoromethyl group to enhance drug potency and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoromethyl moiety can improve efficacy and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced materials with specific electronic or surface properties.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel fluorinated ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other reactions involving activated fluorinated arenes.
• Dye and Pigment Intermediate: Potential use in the synthesis of specialized fluorinated dyes and colorants.

Basic Information

Product Name	1-(Difluoromethyl)-3-Nitro-Benzene
CAS No.	403-25-8
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	3-Nitrobenzal Difluoride; α,α-Difluoro-3-nitro toluene; 3-Nitro-α,α-difluorotoluene; 1-(Difluoromethyl)-3-nitrobenzene; m-Nitro-α,α-difluorotoluene; (Difluoromethyl)-3-nitrobenzene; 3-Nitrobenzylidene Difluoride; 403-25-8
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-3-Nitro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.