Description

3-Fluoro-4-Nitrobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a nitro and a trifluoromethyl group on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Development: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments, where the nitro group can be further functionalized.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluorine groups make it an excellent substrate for nucleophilic aromatic substitution reactions, enabling the introduction of various amines and alkoxides.

Basic Information

Product Name	3-Fluoro-4-Nitrobenzotrifluoride
CAS No.	402-12-0
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	1-Fluoro-2-nitro-4-(trifluoromethyl)benzene; 4-Nitro-3-fluorobenzotrifluoride; 2-Nitro-α,α,α-trifluoro-p-fluorotoluene; Benzene, 1-fluoro-2-nitro-4-(trifluoromethyl)-; α,α,α-Trifluoro-4-fluoro-3-nitrotoluene; 3-Fluoro-4-nitro-α,α,α-trifluorotoluene; p-Fluoro-m-nitrobenzotrifluoride
EINECS	206-933-5

Quality Control

Our 3-Fluoro-4-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.