Description

2-(Trifluoromethyl)-1-Iodo-4-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique combination of electron-withdrawing groups makes it a critical intermediate for constructing complex molecules with tailored electronic properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and anti-infective diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and nitro groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a building block for electron-transport materials and charge-generating compounds in electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying the influence of the trifluoromethyl group on reaction kinetics, molecular conformation, and metabolic stability in drug design.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized dyes and pigments where nitro and halogen groups are integral to color fastness and spectral properties.

Basic Information

Product Name	2-(Trifluoromethyl)-1-Iodo-4-Nitrobenzene
CAS No.	400-75-9
Molecular Formula	C7H3F3INO2
Molecular Weight	316.99 g/mol
Synonyms	1-Iodo-2-(trifluoromethyl)-4-nitrobenzene; 4-Nitro-2-(trifluoromethyl)iodobenzene; 2-Trifluoromethyl-4-nitroiodobenzene; 2-(Trifluoromethyl)-4-nitro-1-iodobenzene; α,α,α-Trifluoro-2-iodo-5-nitro toluene; 2-Iodo-α,α,α-trifluoro-p-nitrotoluene; 2-(Trifluoromethyl)-4-nitroiodobenzene; 2-CF3-4-NO2-C6H3-I
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-1-Iodo-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.