Description

2-Fluoro-5-Nitrobenzotrifluoride is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both a nitro and a trifluoromethyl group on a fluorinated benzene ring, makes it a critical building block for the development of complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic systems to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and nitro groups contribute to biological activity and selectivity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and stability.
• Dye & Pigment Manufacturing: Intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures in medicinal chemistry.
• Research & Development: Essential reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Fluoro-5-Nitrobenzotrifluoride
CAS No.	400-74-8
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	1-Fluoro-2-nitro-4-(trifluoromethyl)benzene; 2-Fluoro-α,α,α-trifluoro-5-nitro toluene; 2-Fluoro-5-nitrobenzylidene trifluoride; 5-Nitro-2-fluorobenzotrifluoride; 2-Fluoro-5-nitro-α,α,α-trifluorotoluene; Benzene, 1-fluoro-2-nitro-4-(trifluoromethyl)-; α,α,α-Trifluoro-2-fluoro-5-nitrotoluene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.