Description

6α,9α-Difluoro-17α-(Furan-2-Yl)Carbonyloxy-11β-Hydroxy-16α-Methyl-3-Oxoandrosta-1,4-Diene-17β-Carbothioic Acid is a high-purity synthetic steroid derivative with a complex molecular architecture designed for advanced pharmaceutical research and development. This compound matters as a critical intermediate or reference standard in the synthesis of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in developing next-generation steroid-based medications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of potent glucocorticoid receptor agonists or antagonists.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in steroid API manufacturing.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties.
• Biochemical Research: Employed in vitro studies to investigate steroid hormone receptor binding affinity and downstream signaling pathways.
• Process Development: Utilized for scaling up and optimizing synthetic routes for new chemical entities (NCEs) in pilot plants.
• Impurity Profiling: Acts as a characterized impurity or degradation product standard for regulatory filings (e.g., ICH guidelines).

Basic Information

Product Name	6α,9α-Difluoro-17α-(Furan-2-Yl)Carbonyloxy-11β-Hydroxy-16α-Methyl-3-Oxoandrosta-1,4-Diene-17β-Carbothioic Acid
CAS No.	397864-40-3
Molecular Formula	C26H28F2O6S
Molecular Weight	506.56 g/mol
Synonyms	6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-(2-furoate); 17β-Carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate; Difluorofuroate steroid intermediate; 397864-40-3 (CAS Name); Fluorinated androstadiene carbothioate; Furan-2-carboxylic acid 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl ester
EINECS	Contact for details

Quality Control

Our 6α,9α-Difluoro-17α-(Furan-2-Yl)Carbonyloxy-11β-Hydroxy-16α-Methyl-3-Oxoandrosta-1,4-Diene-17β-Carbothioic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay, chiral purity determination, and identity confirmation (IR, MS), to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials. For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.