Description

3-[(1R)-3-(Diisopropylamino)-1-Phenylpropyl]-4-Hydroxybenzenemethanol (2E)-2-Butenedioate is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical synthetic intermediate or active pharmaceutical ingredient (API) for the production of targeted therapeutics. It is primarily utilized by pharmaceutical companies and advanced contract research organizations (CROs) engaged in the development of novel drug candidates, particularly in the areas of central nervous system (CNS) and cardiovascular agents. Our supply is characterized by stringent quality control, ensuring batch-to-batch consistency for reliable research and scale-up processes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug molecules.
• Active Pharmaceutical Ingredient (API) Development: Serves as the core active moiety in preclinical and clinical-stage investigational new drugs (INDs).
• Asymmetric Synthesis: Used in stereoselective reactions to construct molecules with specific three-dimensional configurations critical for biological activity.
• Pharmacological Research: Employed in biochemical assays and receptor binding studies to elucidate mechanisms of action.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).

Basic Information

Product Name	3-[(1R)-3-(Diisopropylamino)-1-Phenylpropyl]-4-Hydroxybenzenemethanol (2E)-2-Butenedioate
CAS No.	380636-50-0
Molecular Formula	C26H35NO5
Molecular Weight	441.56 g/mol
Synonyms	(R)-3-[3-(Diisopropylamino)-1-phenylpropyl]-4-hydroxybenzyl alcohol fumarate; Fumaric acid salt of (R)-3-[3-(Diisopropylamino)-1-phenylpropyl]-4-hydroxybenzyl alcohol; (2E)-But-2-enedioic acid;1-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol; 380636-50-0; (R)-3-(3-(Diisopropylamino)-1-phenylpropyl)-4-hydroxybenzyl alcohol fumarate; Fendiline fumarate derivative (chiral).
EINECS	Contact for details

Quality Control

Every batch of 3-[(1R)-3-(Diisopropylamino)-1-Phenylpropyl]-4-Hydroxybenzenemethanol (2E)-2-Butenedioate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as chiral purity, chemical purity (HPLC), and identity confirmation. Our quality protocols are designed to support regulatory filings and ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.