Description

4-Amino-2-Fluoro-5-Iodobenzonitrile is a high-value, multi-functional aromatic building block featuring distinct amino, fluoro, iodo, and cyano substituents. This unique combination of functional groups makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients, particularly in the development of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, anticancer agents, and other small-molecule drugs.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and pesticides, leveraging its halogenated aromatic structure.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in organometallic chemistry and catalysis.
• Material Science: Employed in the research of advanced organic materials, such as organic semiconductors and liquid crystals.
• Chemical Biology: Utilized as a probe or labeling agent in biochemical research due to its reactive handles for bioconjugation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-Amino-2-Fluoro-5-Iodobenzonitrile
CAS No.	380241-60-1
Molecular Formula	C7H4FIN2
Molecular Weight	262.02 g/mol
Synonyms	2-Fluoro-5-iodo-4-aminobenzonitrile; 5-Iodo-2-fluoro-4-aminobenzonitrile; 4-Amino-2-fluoro-5-iodobenzene carbonitrile; Benzonitrile, 4-amino-2-fluoro-5-iodo-; 380241-60-1; 4-Amino-2-fluoro-5-iodo-benzonitrile; 2-Fluoro-4-amino-5-iodobenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-2-Fluoro-5-Iodobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry to ensure identity, potency, and consistency. A Certificate of Analysis (COA) is supplied with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.