Description

1-(4-Fluorophenyl)-1,3-Dihydro-3-Oxo-5-Isobenzofurancarbonitrile is a high-purity, advanced pharmaceutical intermediate with the CAS number 372941-48-5. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering significant value in modern medicinal chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its unique heterocyclic structure.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a core structure for electron-transport or host materials in electronic applications.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and structure-activity relationship (SAR) studies.
• Fine Chemical Production: Acts as a specialized intermediate for custom synthesis and scale-up projects requiring high chemical purity.

Basic Information

Product Name	1-(4-Fluorophenyl)-1,3-Dihydro-3-Oxo-5-Isobenzofurancarbonitrile
CAS No.	372941-48-5
Molecular Formula	C15H8FNO2
Molecular Weight	253.23 g/mol
Synonyms	5-Cyano-1-(4-fluorophenyl)isobenzofuran-3(1H)-one; 5-Cyano-1-(p-fluorophenyl)-1,3-dihydroisobenzofuran-3-one; 1-(4-Fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-5-carbonitrile; 372941-48-5; 1-(p-Fluorophenyl)-1,3-dihydro-3-oxo-5-isobenzofurancarbonitrile; 5-Cyano-1-(4'-fluorophenyl)phthalide
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)-1,3-Dihydro-3-Oxo-5-Isobenzofurancarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.