Description

2-Fluoro-4-Nitrothioanisole is a specialized fluorinated aromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both nitro and thioether functional groups adjacent to a fluorine atom, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring fluorinated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes and pigments, where the nitro and thioether groups influence color and fastness properties.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl structures.
• Organic Synthesis Reagent: Utilized in academic and industrial R&D for exploring new fluorination methodologies and constructing heterocyclic compounds.

Basic Information

Product Name	2-Fluoro-4-Nitrothioanisole
CAS No.	372121-91-0
Molecular Formula	C7H6FNO2S
Molecular Weight	187.19 g/mol
Synonyms	1-Fluoro-2-(methylthio)-5-nitrobenzene; 2-Fluoro-1-methylthio-4-nitrobenzene; 4-Nitro-2-fluorothioanisole; 2-Fluoro-4-nitro-1-(methylthio)benzene; Benzene, 1-fluoro-2-(methylthio)-5-nitro-; 2-Fluoro-4-nitro phenyl methyl sulfide; Methyl 2-fluoro-4-nitrophenyl sulfide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Nitrothioanisole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.