Description

5-(Aminomethyl)-2-Fluorobenzonitrile is a versatile fluorinated aromatic nitrile building block featuring both an aminomethyl and a cyano functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and specialty chemical manufacturers for constructing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Functional Material Precursor: Employed in the synthesis of advanced polymers, liquid crystals, and electronic materials where the fluorine and nitrile groups impart specific physical properties.
• Chemical Biology Probe Synthesis: Utilized in medicinal chemistry for labeling and probing biological targets due to its reactive handles for bioconjugation.
• Custom Synthesis and R&D: A valuable starting material for contract research organizations (CROs) and academic institutions engaged in novel chemical entity discovery.

Basic Information

Product Name	5-(Aminomethyl)-2-Fluorobenzonitrile
CAS No.	368426-86-2
Molecular Formula	C8H7FN2
Molecular Weight	150.15 g/mol
Synonyms	2-Fluoro-5-(aminomethyl)benzonitrile; (3-Cyano-4-fluorophenyl)methanamine; 4-Fluoro-3-(aminomethyl)benzonitrile; 5-(Aminomethyl)-2-fluorobenzonitrile; 2-Fluoro-5-cyanobenzylamine; Benzonitrile, 5-(aminomethyl)-2-fluoro-; 368426-86-2
EINECS	Contact for details

Quality Control

Our 5-(Aminomethyl)-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.