Description

4-(Aminomethyl)-2-Fluorobenzonitrile is a versatile fluorinated aromatic nitrile building block featuring both an aminomethyl and a cyano functional group. This compound is of significant value in pharmaceutical and agrochemical research for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS-targeted drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or optical properties.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis Building Block: Provides a handle for further functionalization via the amine and nitrile groups, enabling the creation of diverse chemical libraries.

Basic Information

Product Name	4-(Aminomethyl)-2-Fluorobenzonitrile
CAS No.	368426-73-7
Molecular Formula	C8H7FN2
Molecular Weight	150.16 g/mol
Synonyms	2-Fluoro-4-(aminomethyl)benzonitrile; 4-(Aminomethyl)-2-fluorobenzonitrile; 2-Fluoro-4-cyanobenzylamine; 4-(Aminomethyl)-2-fluoro-benzonitrile; Benzonitrile, 4-(aminomethyl)-2-fluoro-; (4-Cyano-3-fluorophenyl)methanamine
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-2-Fluorobenzonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.