Description

4-((1,3-Dioxoisoindolin-2-Yl)Methyl)-2-Fluorobenzonitrile is a high-purity, specialized organic intermediate featuring a phthalimide-protected amine moiety and a fluorinated benzonitrile group. This compound is valued for its role as a critical building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for constructing novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the preparation of advanced fluorinated pesticides and herbicides, leveraging the stability and reactivity of the phthalimide group.
• Material Science Research: Serves as a precursor for functionalized polymers and liquid crystals, where the fluorine atom and nitrile group impart specific electronic and physical properties.
• Peptide Mimetics & PROTACs: The protected amine functionality makes it valuable for constructing peptide-like structures and proteolysis-targeting chimeras (PROTACs) in medicinal chemistry.
• Fluorine Chemistry Building Block: Essential for introducing fluorine atoms into complex molecular architectures to modulate bioavailability, metabolic stability, and binding affinity.

Basic Information

Product Name	4-((1,3-Dioxoisoindolin-2-Yl)Methyl)-2-Fluorobenzonitrile
CAS No.	368426-72-6
Molecular Formula	C16H9FN2O2
Molecular Weight	280.26 g/mol
Synonyms	2-Fluoro-4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile; 2-Fluoro-4-(phthalimidomethyl)benzonitrile; 4-(Phthalimidomethyl)-2-fluorobenzonitrile; 4-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-fluorobenzonitrile; 2-Fluoro-4-(1,3-dioxoisoindolin-2-ylmethyl)benzonitrile; N-(2-Cyano-5-fluorobenzyl)phthalimide; 368426-72-6
EINECS	Contact for details

Quality Control

Our production of 4-((1,3-Dioxoisoindolin-2-Yl)Methyl)-2-Fluorobenzonitrile adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized and undergoes rigorous quality testing, including chromatographic purity analysis and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat sources and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.