Description

Ethyl 4-Bromo-4,4-Difluoro-3-Oxobutanoate, also known as Ethyl 4-Bromo-4,4-Difluoro-3-Oxobutyrate, is a high-value fluorinated and brominated building block essential for advanced organic synthesis. Its unique structure, featuring both halogen and carbonyl functionalities, makes it a versatile precursor for constructing complex molecules with tailored properties. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce difluoromethyl and other fluorinated motifs into active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially those requiring difluoromethylene (CF2) groups to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorine incorporation enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials that benefit from fluorine's unique electronic and physical properties.
• Fluorine Chemistry Research: An important reagent in academic and industrial R&D for studying nucleophilic substitution reactions and developing new fluorination methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of custom fluorinated compounds under cGMP or research-grade conditions.

Basic Information

Product Name	Ethyl 4-Bromo-4,4-Difluoro-3-Oxobutanoate / Ethyl 4-Bromo-4,4-Difluoro-3-Oxobutyrate
CAS No.	367922-07-4
Molecular Formula	C6H7BrF2O3
Molecular Weight	245.02 g/mol
Synonyms	Ethyl 4-bromo-4,4-difluoro-3-oxobutanoate; Ethyl 4-bromo-4,4-difluoro-3-oxobutyrate; 4-Bromo-4,4-difluoro-3-oxobutanoic acid ethyl ester; Ethyl 4-bromo-4,4-difluoroacetoacetate; 3-Oxobutanoic acid, 4-bromo-4,4-difluoro-, ethyl ester; 367922-07-4; Ethyl 2-bromo-2,2-difluoroacetate (enolate equivalent)
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-4,4-Difluoro-3-Oxobutanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We support compliance with global regulatory frameworks, including REACH, and can provide material for research under non-GMP or development for cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.