Description

4-(Bromomethyl)-2-Fluorobenzonitrile is a versatile and high-value fluorinated aromatic building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine and bromine functional groups is essential for modulating biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromomethyl group is an excellent handle for further functionalization via Suzuki, Sonogashira, or other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Polymer Modification: Acts as a monomer or modifier for introducing fluorine and reactive sites into specialty polymers.

Basic Information

Product Name	4-(Bromomethyl)-2-Fluorobenzonitrile
CAS No.	366790-50-3
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Fluoro-4-(bromomethyl)benzonitrile; 4-Bromomethyl-2-fluorobenzonitrile; 2-Fluoro-α-bromo-p-tolunitrile; Benzonitrile, 4-(bromomethyl)-2-fluoro-; p-(Bromomethyl)-o-fluorobenzonitrile; 366790-50-3; 2-Fluoro-4-bromomethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.