Description

Icomethasone 21-Mesylate CAS NO 352315-75-4 is a high-purity synthetic corticosteroid derivative, specifically the 21-mesylate ester of icomethasone. This compound is a critical pharmaceutical intermediate and reference standard in the research and development of advanced topical anti-inflammatory and immunosuppressive medications. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and analytical service providers engaged in the synthesis and quality control of novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel corticosteroid active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Research & Development: Serves as a precursor in medicinal chemistry programs targeting glucocorticoid receptor modulators.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research for related steroid drugs.
• Impurity Standard: Employed to identify and quantify process-related impurities in final drug substance batches.

Basic Information

Item	Detail
Product Name	Icomethasone 21-Mesylate
CAS No.	352315-75-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Icomethasone 21-Methanesulfonate; 9α,11β-Dichloro-16α,17α-[(1-methylethylidene)bis(oxy)]-6α-fluoro-21-(methylsulfonyloxy)pregna-1,4-diene-3,20-dione; 6α-Fluoro-9α,11β-dichloro-16α,17α-isopropylidenedioxy-21-mesyloxypregna-1,4-diene-3,20-dione; Icomethasone Mesylate; Icomethasone 21-(Methylsulfonate)
EINECS	Contact for details

Quality Control

Our Icomethasone 21-Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.