Description

4-(Chloromethyl)-3-Fluorobenzonitrile is a versatile and high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its bifunctional reactivity, featuring both a reactive chloromethyl group and a cyano moiety on a fluorinated benzene ring, enabling precise molecular construction. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The chloromethyl group can be utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl structures.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with tailored properties for high-performance coatings and engineering plastics.
• Chemical Biology Probe Development: Useful for synthesizing fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	4-(Chloromethyl)-3-Fluorobenzonitrile
CAS No.	345903-03-9
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	3-Fluoro-4-(chloromethyl)benzonitrile; 4-(Chloromethyl)-3-fluorobenzonitrile; 3-Fluoro-4-chloromethylbenzonitrile; Benzonitrile, 4-(chloromethyl)-3-fluoro-; 4-Chloromethyl-3-fluorobenzonitrile; 3-Fluoro-4-chloromethyl-benzonitrile; 4-(Chloromethyl)-3-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 4-(Chloromethyl)-3-Fluorobenzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) is provided with each shipment, documenting identity (IR, NMR), assay, and related substances. We support custom synthesis to meet specific pharmacopeial (USP/EP) or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.