Description

Benzonitrile, 3,6-Difluoro-2-Hydroxy- (9Ci) CAS NO 344764-39-2 is a high-purity fluorinated benzonitrile derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both nitrile and hydroxyl groups on a difluorinated aromatic ring, makes it a versatile building block for constructing complex molecules with tailored properties. This compound is essential for R&D and production in the pharmaceutical and agrochemical sectors, where precise fluorination is required to modulate bioactivity, metabolic stability, and physicochemical characteristics of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs where fluorine atoms enhance potency and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluoro-hydroxy benzonitrile core contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to enhanced thermal stability, dielectric anisotropy, and optical performance.
• Polymer & Specialty Chemicals: Employed in the synthesis of high-performance polymers, coatings, and specialty additives that benefit from the introduction of fluorine for increased chemical resistance and durability.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and constructing novel heterocyclic compounds.
• Material Science: Used in the development of advanced organic semiconductors and photoactive materials for optoelectronic applications.

Basic Information

Product Name	Benzonitrile, 3,6-Difluoro-2-Hydroxy- (9Ci)
CAS No.	344764-39-2
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	3,6-Difluoro-2-hydroxybenzonitrile; 2-Cyano-4,5-difluorophenol; 4,5-Difluoro-2-hydroxybenzonitrile; 2-Hydroxy-3,6-difluorobenzonitrile; Phenol, 2-cyano-4,5-difluoro-; 4,5-Difluorosalicylonitrile; 2-Hydroxy-4,5-difluorobenzonitrile; 3,6-Difluoro-2-hydroxybenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3,6-Difluoro-2-Hydroxy- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, for comprehensive identity confirmation and impurity profiling. Certificates of Analysis (COA) detailing all critical quality attributes are provided with each shipment. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.