Description

2-Ethynyl-1-Fluoro-4-Nitro-Benzene is a specialized aromatic building block featuring a unique combination of an ethynyl group, a fluorine atom, and a nitro substituent. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical and life sciences industries for constructing novel chemical entities and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the nitro and fluoro groups can enhance biological activity.
• Material Science: Acts as a monomer or precursor in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it a valuable substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Dye & Pigment Synthesis: Utilized as an intermediate in the production of specialized dyes and organic pigments.
• Academic & Industrial R&D: Employed in research laboratories for methodological studies and the exploration of new synthetic pathways.

Basic Information

Product Name	2-Ethynyl-1-Fluoro-4-Nitro-Benzene
CAS No.	343866-99-9
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	1-Fluoro-2-ethynyl-4-nitrobenzene; 2-Ethynyl-4-fluoro-1-nitrobenzene; 4-Fluoro-2-(ethynyl)-1-nitrobenzene; 2-Fluoro-5-nitrobenzeneacetylene; 2-Fluoro-5-nitrophenylacetylene; 5-Nitro-2-fluorophenylacetylene; (2-Fluoro-5-nitrophenyl)ethyne
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-1-Fluoro-4-Nitro-Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.