Description

Benzonitrile, 2,4-Difluoro-5-Methyl- (9Ci) is a fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methyl substituents on the benzonitrile core, which allows for precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where it serves as a key intermediate for creating complex heterocycles and functionalized aromatics. CAS No. 329314-68-3.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoro-methylbenzonitrile moiety contributes to improved bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, polymers, and organic electronic materials to fine-tune their properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Benzonitrile, 2,4-Difluoro-5-Methyl- (9Ci)
CAS No.	329314-68-3
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2,4-Difluoro-5-methylbenzonitrile; 5-Methyl-2,4-difluorobenzonitrile; 2,4-Difluoro-5-methyl-benzonitrile; 3,5-Difluoro-4-methylbenzonitrile; 2,4-Difluoro-5-methylphenyl cyanide; 329314-68-3; 5-Methyl-2,4-difluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 2,4-Difluoro-5-Methyl- (9Ci) is produced and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.