Description

3-Chloro-5-Fluorobenzonitrile is a versatile and high-purity aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the halogenated benzonitrile core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers for high-performance polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A valuable building block for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Custom Synthesis: Used by fine chemical manufacturers for contract synthesis of proprietary compounds and specialty chemicals.

Basic Information

Product Name	3-Chloro-5-Fluorobenzonitrile
CAS No.	327056-73-5
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	3-Chloro-5-fluorobenzonitrile; 5-Fluoro-3-chlorobenzonitrile; Benzonitrile, 3-chloro-5-fluoro-; 3-Chloro-5-fluorophenyl cyanide; 327056-73-5; 3-Cl-5-F-C6H3-CN
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing purity, identity, and impurity profiles. We are committed to meeting the stringent requirements of cGMP and ISO standards for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Max. Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.