Description

(D-Leu7)-Histrelin CAS NO 321709-43-7 is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) with a D-amino acid substitution at the seventh position. This modification confers enhanced metabolic stability and altered receptor binding affinity, making it a valuable research tool for studying GnRH receptor signaling pathways and endocrine function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroendocrinology, oncology, and peptide drug discovery.

Application

• Biomedical Research: A critical reference standard and active probe for investigating the structure-activity relationships (SAR) of GnRH analogs and their interaction with receptor subtypes.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the design and synthesis of novel peptide-based therapeutics targeting hormone-dependent conditions.
• Endocrinology Studies: Used in in vitro and in vivo models to study the regulation of the hypothalamic-pituitary-gonadal (HPG) axis and the effects of GnRH modulation.
• Oncology Research: Investigated for its potential role in influencing the growth of hormone-sensitive cancers, such as prostate and breast cancer, through GnRH receptor pathways.
• Analytical Standard: Employed as a high-purity calibrant in chromatographic (HPLC, LC-MS) and spectroscopic analyses for method development and quality control of related peptides.

Basic Information

Item	Detail
Product Name	(D-Leu7)-Histrelin
CAS No.	321709-43-7
Molecular Formula	C₆₆H₈₆N₁₈O₁₂
Molecular Weight	1323.5 g/mol
Synonyms	Histrelin, D-Leu7 analog; [D-Leucine7]-Histrelin; GnRH (6-10), His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; LHRH agonist analog; Gonadorelin (6-10) analog; Azaline B analog (related compound); Des-Gly10, Pro9-NHET LHRH ethylamide analog
EINECS	Contact for details

Quality Control

Every batch of (D-Leu7)-Histrelin is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to support research and development applications, ensuring identity, purity, and consistency. A Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, and related substances is supplied with each shipment. Our quality systems are designed to meet the stringent requirements of pharmaceutical research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.