Description

(D-Leu7)-Triptorelin CAS NO 321709-37-9 is a synthetic peptide analog of the natural gonadotropin-releasing hormone (GnRH), specifically modified at the seventh amino acid position with D-leucine. This structural modification is critical for enhancing its metabolic stability and receptor binding affinity, making it a valuable research-grade compound for advanced pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the study of endocrinology, oncology, and the development of novel therapeutic agents targeting hormone-sensitive pathways.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the R&D of novel GnRH agonist and antagonist therapies.
• Endocrinology Studies: Used in preclinical research to investigate the regulation of the hypothalamic-pituitary-gonadal axis and related hormonal feedback mechanisms.
• Oncology Research: Employed in studies focusing on hormone-dependent cancers, such as prostate and breast cancer, to explore treatment modalities involving hormonal suppression.
• Peptide Chemistry & Biochemistry: Acts as a model compound for studying peptide stability, receptor-ligand interactions, and structure-activity relationships (SAR) in synthetic peptide design.
• Analytical Standard: Used as a high-purity calibrant and system suitability standard in analytical methods development, including HPLC and LC-MS, for quality control in peptide manufacturing.

Basic Information

Product Name	(D-Leu7)-Triptorelin
CAS No.	321709-37-9
Molecular Formula	C₆₄H₈₂N₁₈O₁₂
Molecular Weight	1311.5 g/mol
Synonyms	D-Leu-6-GnRH I; D-Leu-6-LHRH; [D-Leu7]-Triptorelin; (D-Leucine-7)-Triptorelin; Gonadorelin (6-D-Leu) analog; Triptorelin D-Leu7 derivative; 5-Oxo-Pro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; P-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-Gly-NH₂ (acetate)
EINECS	Contact for details

Quality Control

Our (D-Leu7)-Triptorelin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (IC)	5.0% - 12.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.