Description

2,5-Bis(Trifluoromethyl)Phenylacetonitrile is a high-value, multi-functional fluorinated aromatic nitrile building block. Its unique structure, featuring two electron-withdrawing trifluoromethyl groups, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine's beneficial properties into their molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets, where the trifluoromethyl groups enhance metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging fluorine's ability to improve biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, where its structure contributes to desired electronic properties and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis and cross-coupling reactions.
• Advanced Material Research: Employed in academic and industrial R&D for creating novel fluorinated compounds with tailored properties for electronics, coatings, and sensors.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Phenylacetonitrile
CAS No.	302911-99-5
Molecular Formula	C10H5F6N
Molecular Weight	253.15 g/mol
Synonyms	2,5-Bis(trifluoromethyl)benzyl cyanide; (2,5-Bis(trifluoromethyl)phenyl)acetonitrile; α-Cyano-2,5-bis(trifluoromethyl)toluene; 2,5-Di(trifluoromethyl)phenylacetonitrile; 2,5-Bis(trifluoromethyl)benzeneacetonitrile; 2,5-Bis(trifluoromethyl)benzyl nitrile; 302911-99-5; 2,5-Bis(trifluoromethyl)benzenecetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2,5-Bis(Trifluoromethyl)Phenylacetonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.