Description

Cyclopropanecarbonitrile, 2-(4-Fluorophenyl)-, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its rigid cyclopropane ring and nitrile functionality, which are critical for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where stereochemistry and molecular conformation directly influence biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the design and synthesis of advanced herbicides, fungicides, and insecticides, where the cyclopropane moiety can enhance stability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its ability to act as a mechanism-based inhibitor.

Basic Information

Product Name	Cyclopropanecarbonitrile, 2-(4-Fluorophenyl)-, (1R,2R)-Rel- (9Ci)
CAS No.	301861-15-4
Molecular Formula	C10H8FN
Molecular Weight	161.18 g/mol
Synonyms	(1R,2R)-2-(4-Fluorophenyl)cyclopropanecarbonitrile; rel-(1R,2R)-2-(4-Fluorophenyl)cyclopropanecarbonitrile; (1R,2R)-2-(p-Fluorophenyl)cyclopropanecarbonitrile; 2-(4-Fluorophenyl)cyclopropanecarbonitrile (1R,2R)-rel-; (1R,2R)-rel-2-(4-Fluorophenyl)cyclopropanecarbonitrile; 301861-15-4; (1R,2R)-2-(4-Fluorophenyl)cyclopropanenitrile
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarbonitrile, 2-(4-Fluorophenyl)-, (1R,2R)-Rel- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and GC/HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,2R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.