Description

Befunolol CAS NO 39552-01-7 is a potent and selective β-adrenergic receptor antagonist (β-blocker) used primarily in pharmaceutical research and development. Its significance lies in its utility as a key intermediate or reference standard for synthesizing and analyzing cardiovascular and ophthalmic medications. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and analytical service providers focused on developing new therapeutic agents or ensuring the quality of existing β-blocker formulations.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced β-blocker drug substances.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of pharmaceutical products via HPLC, GC, or LC-MS.
• Biochemical Research: Employed in pharmacological studies to investigate β-adrenergic receptor binding, selectivity, and signal transduction pathways.
• Active Pharmaceutical Ingredient (API) Development: Acts as a starting material or precursor in the development and scale-up of new ophthalmic or systemic β-blocker APIs.
• Impurity Profiling: Utilized as a certified reference material to identify and quantify related substances and degradation products in drug formulations.

Basic Information

Product Name	Befunolol
CAS No.	39552-01-7
Molecular Formula	C16H22ClNO3
Molecular Weight	311.80 g/mol
Synonyms	Befunolol; Befunolol Hydrochloride; 2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran; 1-[2-(5-Chloro-2-benzofuranyl)-2-oxoethyl]-2-isopropylaminoethanol; BFE-60; Bentos; Betaclar; Glauconex; Bentos®
EINECS	Contact for details

Quality Control

Our Befunolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications suitable for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.