Description

Befunolol Hydrochloride CAS NO 39543-79-8 is a selective β-adrenergic receptor antagonist (β-blocker) in its hydrochloride salt form, offering enhanced stability and solubility for pharmaceutical manufacturing. This compound is critical for the development and production of ophthalmic solutions used to manage conditions like glaucoma and ocular hypertension by reducing intraocular pressure. It is primarily required by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and contract development and manufacturing organizations (CDMOs) serving the global ophthalmic therapeutics market.

Application

• Active Pharmaceutical Ingredient (API) in ophthalmic solutions for glaucoma treatment.
• Reference Standard for analytical method development and quality control in pharmaceutical laboratories.
• Research Chemical for pharmacological studies on β-adrenergic receptors and cardiovascular research.
• Intermediate in the synthesis of more complex pharmaceutical compounds.
• Formulation Development for creating novel drug delivery systems, such as sustained-release eye drops.

Basic Information

Product Name	Befunolol Hydrochloride
CAS No.	39543-79-8
Molecular Formula	C16H24ClNO3 • HCl
Molecular Weight	342.28 g/mol
Synonyms	Befunolol HCl; 2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran Hydrochloride; (RS)-1-{2-Acetyl-7-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran-5-yloxy}-3-isopropylaminopropan-2-ol Hydrochloride; BF-5; OPC-1427; Kerlone (brand name reference); Betaxolol analogue
EINECS	Contact for details

Quality Control

Our Befunolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA), including results for assay, purity, and specified impurities, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.