Description

9-Fluoro-11Beta,17-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(9Z,12Z)-Octadeca-9,12-Dienoate is a high-purity, synthetic corticosteroid derivative, specifically a linoleate ester prodrug. This compound matters for its role as a key pharmaceutical intermediate in the development of potent topical anti-inflammatory and immunosuppressive agents. Pharmaceutical R&D and manufacturing companies need this precise chemical building block to synthesize advanced corticosteroid APIs, ensuring consistent quality and efficacy in final drug formulations.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of high-potency topical corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for creating novel prodrug formulations with enhanced dermal penetration and localized activity.
• Dermatological Preparations: A key component in the manufacture of creams, ointments, and lotions for treating psoriasis, eczema, and dermatitis.
• Veterinary Medicine: Employed in the development of anti-inflammatory treatments for animals.
• Biochemical Research: Serves as a reference standard and tool compound in steroid receptor binding and metabolic pathway studies.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for corticosteroid manufacturing.

Basic Information

Product Name	9-Fluoro-11Beta,17-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(9Z,12Z)-Octadeca-9,12-Dienoate
CAS No.	39026-39-6
Molecular Formula	C40H59FO6
Molecular Weight	654.89 g/mol
Synonyms	Flumethasone Pivalate Linoleate; Flumethasone Pivalate (Linoleate Ester); 9α-Fluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate 17-linoleate; Flumethasone Pivalate (Mixed Ester); Flumethasone 21-Pivalate 17-Linoleate; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-pivalate 17-linoleate; CAS 39026-39-6
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(9Z,12Z)-Octadeca-9,12-Dienoate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and identity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.