Description

7-Deoxydoxorubicinone is a key anthracycline aglycone intermediate, structurally related to the potent anticancer agent doxorubicin. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel anthracycline derivatives and analogs. It serves as a critical building block for medicinal chemists and researchers in the oncology and life sciences sectors, enabling the exploration of new therapeutic agents with potentially improved efficacy and reduced side-effect profiles.

Application

• Pharmaceutical Intermediate: Primary use as a core scaffold for the synthesis of novel anthracycline-based chemotherapeutic agents.
• Anticancer Research: Critical starting material for developing and studying new doxorubicin analogs with modified pharmacological properties.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to understand the impact of the sugar moiety on anthracycline activity and toxicity.
• Biochemical Research: Employed as a reference standard or probe in studies investigating the mechanism of action of topoisomerase II inhibitors.
• API Development: Serves as a precursor in the development and scale-up processes for active pharmaceutical ingredients (APIs) within the anthracycline class.

Basic Information

Product Name	7-Deoxydoxorubicinone
CAS No.	38554-25-5
Molecular Formula	C₂₁H₁₈O₈
Molecular Weight	398.36 g/mol
Synonyms	7-Deoxyaglycone of Doxorubicin; 7-Deoxydoxorubicin Aglycone; 7-Deoxydoxorubicinone; Doxorubicinone, 7-deoxy-; 7-Deoxy-13-dihydrodoxorubicinone; (7S,9S)-7-Deoxy-9-hydroxy-10-[(2S,4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-6,11-dioxo-8,10-dihydro-7H-tetracene-5,12-dione; 7-Deoxy-13-dihydrocarminomycinone
EINECS	Contact for details

Quality Control

Our 7-Deoxydoxorubicinone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.