Description

Penbutolol is a non-selective β-adrenergic blocking agent, also known as a β-blocker, with intrinsic sympathomimetic activity. This compound is a critical active pharmaceutical ingredient (API) used in the research and development of cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel drug formulations and clinical studies.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of β-blocker medications for hypertension and angina.
• Reference Standard: Used as a high-purity calibrant in analytical laboratories for quality control and method development.
• Biochemical Research: Serves as a key tool for studying β-adrenergic receptor mechanisms and cardiovascular pharmacology.
• Process Development: Employed in scaling up synthesis routes for commercial pharmaceutical production.
• Impurity Profiling: Acts as a primary standard to identify and quantify related substances in drug substances and products.
• Academic Research: Utilized in university and institutional labs for pharmacological and medicinal chemistry studies.

Basic Information

Product Name	Penbutolol
CAS No.	38363-40-5
Molecular Formula	C18H29NO3
Molecular Weight	307.43 g/mol
Synonyms	Penbutolol Sulfate; (±)-Penbutolol; (RS)-Penbutolol; 1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol; Hoe 893d; Betapressin; Ipobar; Levatol; Terbuclomine
EINECS	253-908-4

Quality Control

Our Penbutolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and research chemicals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.