Description

n-Methyl Desloratadine is a high-purity pharmaceutical intermediate and active metabolite of desloratadine. This compound is critical for research and development in the synthesis of advanced antihistamine drugs, offering a pathway to novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on respiratory and allergy medication development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of desloratadine and related antihistamine APIs.
• Metabolite Reference Standard: Used in analytical laboratories for pharmacokinetic studies and bioanalytical method development.
• Drug Discovery & Development: Serves as a crucial scaffold for medicinal chemistry research aimed at creating new H1-receptor antagonists.
• Quality Control & Impurity Profiling: Employed as a certified reference material (CRM) to identify and quantify related substances in drug products.
• Academic & Contract Research: Utilized in university and CRO settings for pharmacological research on allergy and inflammation pathways.

Basic Information

Product Name	n-Methyl Desloratadine
CAS No.	38092-89-6
Molecular Formula	C20H21ClN2
Molecular Weight	324.85 g/mol
Synonyms	8-Chloro-6,11-dihydro-11-(4-methylpiperazin-1-yl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Desloratadine N-Methyl Metabolite; Norastemizole Impurity; 8-Chloro-11-(4-methyl-1-piperazinyl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Descarboethoxyloratadine N-Methyl; MK-9347; Sch 34117 Metabolite
EINECS	Contact for details

Quality Control

Our n-Methyl Desloratadine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via IR and MS, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.