Description

Diethylaminosulfur Trifluoride (DAST) is a highly reactive fluorinating agent widely used in organic synthesis. Its primary value lies in its ability to efficiently convert alcohols, aldehydes, and ketones into the corresponding alkyl fluorides, acyl fluorides, and gem-difluorides, respectively. This compound is an indispensable reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the precise introduction of fluorine atoms to modulate the biological activity and physical properties of target molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective fluorination of complex molecules, creating active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability.
• Agrochemical Production: Used in the synthesis of fluorinated pesticides and herbicides, where the fluorine atom improves efficacy and environmental persistence.
• Fluoroorganic Compound Manufacture: Essential for producing specialty chemicals, liquid crystals for displays, and fluorinated polymers with unique surface properties.
• Deoxofluorination Reactions: Efficiently replaces hydroxyl groups with fluorine in carbohydrate and nucleoside chemistry for drug discovery.
• Laboratory-Scale Research: A staple fluorination tool in R&D laboratories for exploring new chemical entities and reaction pathways.
• Material Science: Employed in the surface modification and creation of fluorinated building blocks for advanced polymeric materials.

Basic Information

Product Name	Diethylaminosulfur Trifluoride
CAS No.	38078-09-0
Molecular Formula	C₄H₁₀F₃NS
Molecular Weight	161.19 g/mol
Synonyms	DAST; Diethylaminosulfur Trifluoride; (Diethylamino)sulfur Trifluoride; Diethylaminotrifluorosulfurane; N,N-Diethylaminosulfur Trifluoride; Et₂NSF₃; NSC 13315; Diethylaminotris(fluorido)sulfur(IV)
EINECS	253-739-8

Quality Control

Our Diethylaminosulfur Trifluoride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay by NMR or titration and impurity profiling, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent decomposition. Isolate from strong oxidizers, bases, and water sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Purity (GC)	≥ 90.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.