Description

5-Amino-2-Fluorobenzonitrile is a high-purity aromatic nitrile derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both an amino and a fluorine substituent on the benzonitrile core, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic semiconductors due to its electron-withdrawing nitrile group and potential for functionalization.
• Fluorinated Compound Library: An essential building block for medicinal chemistry teams constructing diverse compound libraries for high-throughput screening (HTS).
• Dye and Pigment Intermediate: Utilized in the production of specialized fluorinated dyes and pigments, offering improved lightfastness and color properties.

Basic Information

Product Name	5-Amino-2-Fluorobenzonitrile
CAS No.	37705-82-1
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	2-Fluoro-5-aminobenzonitrile; 5-Amino-2-fluorobenzene carbonitrile; 2-Fluoro-5-cyanobenzeneamine; 2-Fluoro-5-cyanoaniline; Benzonitrile, 5-amino-2-fluoro-; 5-Cyano-2-fluoroaniline; 2-Fluoro-5-aminobenzene nitrile
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.