Description

Bleomycinic Acid CAS NO 37364-66-2 is a key intermediate in the synthesis of bleomycin antibiotics, a class of glycopeptide-derived compounds with significant antitumor activity. Its precise chemical structure is critical for ensuring the efficacy and purity of the final active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for pharmaceutical manufacturers and research institutions engaged in oncology drug development and production.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of Bleomycin sulfate and related antitumor antibiotic APIs.
• Oncology Research: Used in biochemical and pharmacological research to study the mechanism of action of bleomycin-family drugs.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical labs.
• Process Development: Employed in the development and scale-up of optimized synthetic routes for bleomycin-type chemotherapeutic agents.

Basic Information

Product Name	Bleomycinic Acid
CAS No.	37364-66-2
Molecular Formula	C55H84N17O21S3
Molecular Weight	1415.6 g/mol
Synonyms	Bleomycinic acid; NSC-125066; Bleomycin A; Bleomycinic acid (VAN); Bleomycin A2 Hydrochloride precursor; 6-[[2-[[1-[[2-[[(2S,3S,4R,5S,6S)-6-[[(2S,3S,4S,5R)-5-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3,4-dihydroxyoxan-2-yl]methoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]-2-(1H-imidazol-5-yl)ethyl]-2-methyl-1,3-thiazole-4-carbonyl]amino]-1H-imidazol-4-yl]-1-methyl-4,10,13-trioxo-3,16,19-trioxa-5,9,12-triazatricos-20-en-23-oic acid
EINECS	Contact for details

Quality Control

Our Bleomycinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.