Description

Metoprolol is a selective β1-adrenergic receptor blocking agent, widely recognized for its cardiovascular applications. Its high purity and consistent quality are critical for ensuring the efficacy and safety of final pharmaceutical formulations. This active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry developing treatments for hypertension, angina, and heart failure. Metoprolol CAS NO 37350-58-6 is supplied under stringent quality control to meet the demanding requirements of global drug production.

Application

As a key cardiovascular agent, Metoprolol is utilized in various therapeutic areas:

• Hypertension Treatment: Primary API in tablets and extended-release formulations for managing high blood pressure.
• Angina Pectoris: Used in medications to prevent chest pain caused by reduced blood flow to the heart.
• Heart Failure Management: A component in therapies to improve survival and reduce hospitalization in patients with heart failure.
• Cardiac Arrhythmias: Employed in certain formulations to help control irregular heartbeats.
• Post-Myocardial Infarction: Integral to secondary prevention regimens following a heart attack.
• Pharmaceutical Research: Serves as a reference standard and raw material in R&D for new cardiovascular drug delivery systems.
• Generic Drug Manufacturing: A fundamental building block for producers of generic metoprolol succinate and tartrate medications.

Basic Information

Product Name	Metoprolol
CAS No.	37350-58-6
Molecular Formula	C15H25NO3
Molecular Weight	267.36 g/mol
Synonyms	Metoprolol Base; (±)-Metoprolol; Lopressor; Toprol-XL; Betaloc; Seloken; 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol; DL-Metoprolol
EINECS	253-476-3

Quality Control

Our Metoprolol is manufactured and tested to meet the highest pharmacopeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, potency, and purity, with strict limits on related substances and residual solvents. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with each shipment to ensure full traceability and compliance for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities: NMT 0.5% Any individual impurity: NMT 0.1%
Water (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Specific Rotation	-0.10° to +0.10° (c=5 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.