Description

Bucumolol Hydrochloride is a potent, selective β-adrenergic receptor antagonist (β-blocker) used in pharmaceutical research and development. This compound is crucial for studying cardiovascular pharmacology, particularly in the context of hypertension, angina, and arrhythmia. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced β-blocker drug candidates.
• Cardiovascular Research: Used as a reference standard or active compound in studies investigating heart rate regulation, blood pressure control, and myocardial function.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening assays for β-adrenergic receptor activity.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research to understand drug disposition and identify potential metabolites.
• Formulation Development: Acts as an active pharmaceutical ingredient (API) in prototype formulations for dosage form studies (e.g., tablets, capsules).
• Quality Control Reference: Provides a certified reference material for analytical method development and impurity profiling in pharmaceutical quality control laboratories.

Basic Information

Item	Details
Product Name	Bucumolol Hydrochloride
CAS No.	36625-96-4
Molecular Formula	C18H28N2O3·HCl
Molecular Weight	356.89 g/mol
Synonyms	Bucumolol HCl; 1-(tert-Butylamino)-3-[(6-methyl-2-chromanyl)oxy]-2-propanol Hydrochloride; (±)-Bucumolol Hydrochloride; 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(6-methyl-2H-1-benzopyran-2-yl)oxy]-, hydrochloride; K-5103; CS-359; Chroman derivative β-blocker
EINECS	Contact for details

Quality Control

Our Bucumolol Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.