Description

2-Bromo-4-(Trifluoromethyl)Benzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethylphenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the bromine atom serves as a handle for further functionalization via cross-coupling reactions.
• Liquid Crystal & OLED Materials: Serves as a building block for creating novel organic electronic materials, where the combination of the nitrile group and fluorine atoms influences molecular polarity and mesomorphic properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations, enabling rapid diversification of chemical libraries.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on aromatic systems in medicinal and materials chemistry.

Basic Information

Product Name	2-Bromo-4-(Trifluoromethyl)Benzonitrile
CAS No.	35764-15-9
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-α,α,α-trifluoro-p-tolunitrile; 4-Cyano-3-bromobenzotrifluoride; 2-Bromo-4-(trifluoromethyl)benzonitrile; Benzonitrile, 2-bromo-4-(trifluoromethyl)-; 3-Bromo-4-cyanobenzotrifluoride; p-Cyanobenzotrifluoride, 2-bromo-; 2-Bromo-α,α,α-trifluoro-4-cyanotoluene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.