Description

Daunorubicin Oxime Hydrochloride is a chemically modified derivative of the anthracycline antibiotic daunorubicin, designed to enhance its therapeutic profile. This compound is of significant interest in pharmaceutical research and development, particularly for its potential to serve as a key intermediate or active pharmaceutical ingredient (API) in novel oncology treatments. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the synthesis and evaluation of next-generation chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced daunorubicin analogs and related anticancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, drug resistance, and structure-activity relationships (SAR) of anthracycline derivatives.
• Active Pharmaceutical Ingredient (API) Development: Serves as a potential API or precursor in the formulation of injectable chemotherapeutic products under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation Studies: Employed in the development of antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its modifiable oxime functional group.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	Daunorubicin Oxime Hydrochloride
CAS No.	34610-60-1
Molecular Formula	C27H30ClN2O11
Molecular Weight	605.99 g/mol
Synonyms	Daunorubicin Oxime HCl; Daunorubicin, O-(hydroxyimino)-, hydrochloride; Daunomycin Oxime Hydrochloride; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione oxime hydrochloride; 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, oxime, hydrochloride, (8S-cis)-; Cerubidine Oxime Hydrochloride
EINECS	Contact for details

Quality Control

Our Daunorubicin Oxime Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines, and specifications can be tailored to meet specific project requirements, including those for GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.