Description

Cortisol Acetonide is a synthetic corticosteroid derivative, specifically the 21-acetonide of cortisol. This compound is valued for its enhanced stability and modified pharmacological profile compared to its parent molecule, making it a key intermediate in advanced pharmaceutical synthesis. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel anti-inflammatory and dermatological therapeutics.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of more complex corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in biochemical and pharmacological research to study steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Dermatological Product Development: Investigated for potential use in the formulation of topical creams or ointments targeting inflammatory skin conditions.

Basic Information

Product Name	Cortisol Acetonide
CAS No.	34332-34-8
Molecular Formula	C24H34O6
Molecular Weight	418.53 g/mol
Synonyms	Cortisol 21-Acetonide; Hydrocortisone Acetonide; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione Cyclic 21-Acetal with Acetone; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione Cyclic 21-Acetal with Acetone; NSC 113926; 21-Deoxy-21-(2-hydroxy-2-propanyl)-11β,17α-dihydroxypregn-4-ene-3,20-dione
EINECS	Contact for details

Quality Control

Our Cortisol Acetonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.