Description

Pregna-1,4-Diene-3,11,20-Trione, 17-Hydroxy-21-(Phosphonooxy)-, Disodium Salt is a high-purity, water-soluble steroid phosphate derivative. This compound is a critical intermediate in the synthesis of advanced pharmaceutical actives, particularly in the development of potent anti-inflammatory corticosteroids. It is essential for research and manufacturing organizations in the pharmaceutical and life sciences sectors requiring precise, high-quality building blocks for complex synthesis. Its disodium salt form enhances stability and solubility for specific formulation needs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent glucocorticoid drugs, such as certain corticosteroid prodrugs.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies related to steroid metabolism and hormone action pathways.
• Steroid Chemistry Development: Serves as a versatile building block for medicinal chemists exploring new derivatives with modified pharmacological profiles.
• Veterinary Pharmaceutical Manufacturing: Employed in the production of anti-inflammatory treatments for animal health applications.
• Advanced Drug Delivery Systems: Investigated for use in prodrug formulations where phosphate moieties can influence bioavailability and targeting.

Basic Information

Product Name	Pregna-1,4-Diene-3,11,20-Trione, 17-Hydroxy-21-(Phosphonooxy)-, Disodium Salt
CAS No.	33903-70-7
Molecular Formula	C21H25Na2O9P
Molecular Weight	486.37 g/mol
Synonyms	21-Phosphonoxy Prednisolone Disodium Salt; Prednisolone 21-Phosphate Disodium Salt; 17-Hydroxypregna-1,4-diene-3,11,20-trione 21-(dihydrogen phosphate) disodium salt; Prednisolone Sodium Phosphate (related compound); NSC 10481; Disodium Prednisolone Phosphate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate) disodium salt
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,11,20-Trione, 17-Hydroxy-21-(Phosphonooxy)-, Disodium Salt is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.