Description

Hydrocortisone 21-(Sodium 3-Sulphonatobenzoate) is a water-soluble derivative of the natural glucocorticoid hydrocortisone, specifically designed for enhanced formulation stability and bioavailability. This modification is critical for creating injectable and topical pharmaceutical preparations where solubility and precise dosing are paramount. It is an essential active pharmaceutical ingredient (API) and intermediate for manufacturers in the pharmaceutical, biotechnology, and advanced dermatological sectors requiring high-purity steroid compounds.

Application

• Pharmaceutical API: Primary use as an active ingredient in injectable anti-inflammatory and immunosuppressive medications.
• Topical Formulations: Key component in creams, ointments, and gels for treating eczema, psoriasis, and allergic dermatitis.
• Ophthalmic Solutions: Used in eye drops for treating inflammatory eye conditions.
• Veterinary Medicine: Formulated for anti-inflammatory treatments in companion and livestock animals.
• Research & Development: Standard reference compound and intermediate in steroid chemistry and drug discovery.
• Bioconjugation & Prodrug Synthesis: Serves as a versatile intermediate for creating targeted drug delivery systems.

Basic Information

Product Name	Hydrocortisone 21-(Sodium 3-Sulphonatobenzoate)
CAS No.	33767-03-2
Molecular Formula	C28H33NaO8S
Molecular Weight	552.61 g/mol
Synonyms	Hydrocortisone 21-(Sodium 3-Sulfobenzoate); Hydrocortisone 21-Hemisuccinate Sodium Sulfobenzoate; Hydrocortisone Sodium Succinate Sulfobenzoate; Cortisol 21-(Sodium 3-Sulphonatobenzoate); 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(Sodium 3-Sulphonatobenzoate); Water-Soluble Hydrocortisone Derivative; Hydrocortisone Sulfobenzoate Sodium Salt
EINECS	Contact for details

Quality Control

Our Hydrocortisone 21-(Sodium 3-Sulphonatobenzoate) is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) documenting results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.